Long‐chain derivatives with a hexahydrothioxotetrazine moiety as potential antimicrobial agents

A series of hexahydrothioxotetrazine‐containing compounds I–IV were evaluated for their antimicrobial activity. Fungi (Aspergillus sydowii, A. nidulari, A. terreus, Fusarium solanum, Trichoderma viridae, T. lignorum, Rhizopus arrhitus andCandida albicans) and bacteria (Escherichia coli, Salmonella sp.,Pseudomonas aeruginosa, bacillus sp.,Staphylococcus aureus, Klebsella sp.,Shigella sp. andStreptococcus faecalis) were used for this examination. Compounds I–III showed 90% growth inhibition against a large number of fungi. Two compounds (II and III) have shown significant antibacterial activity. The most striking feature of this study is that compound II, which does not carry an ester function, is the most potent antifungal and antibacterial agent. In general, these promising compounds may be of commercial significance in the future and therefore need developmental studies.