2004•BiopolymersRequires access

Characterization of collagen‐like heterotrimers: Implications for triple‐helix stability

Rita Berisio, Vincenzo Granata, Luigi Vitagliano, Adriana Zagari

Abstract

This article deals with the effects of proline hydroxylation on collagen triple-helix stability, an issue that is still under discussion. To investigate the structural determinants of triple-helix stabilization by hydroxyproline (Hyp), we here characterized spectroscopically triple-helix heterotrimers containing both chains of (Pro-Pro-Gly)10 and (Pro-Hyp-Gly)10. Results are discussed in relation to the various triple-helix stabilization mechanisms.

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Key concepts: Triple helix, Collagen helix, Chemistry, Hydroxylation, Hydroxyproline, Helix (gastropod), Proline, Stereochemistry