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Aldosterone Secretion in Magnesium-Deficient Rats

H. Earl Ginn, Robert Cade, Theresa J. McCallum, MELVIN FREGLEY

Open publisher page 52 citations

Abstract

Decreased muscle potassium and increased sodium in rats made magnesium deficient suggested the possibility of increased aldosterone secretion. Muscle and plasma electrolytes and secretion of aldosterone and corticosterone in magnesium-deficient rats were compared with the same values in pair-fed controls. Aldosterone secretion by the magnesium-depleted animals was increased, while corticosterone secretion was decreased. Altered steroid secretion adequately explains the altered sodium and potassium metabolism. (Endocrinology80: 969, 1967)

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What this paper is about

Decreased muscle potassium and increased sodium in rats made magnesium deficient suggested the possibility of increased aldosterone secretion. Muscle and plasma electrolytes and secretion of aldosterone and corticosterone in magnesium-deficient rats were compared with the same values in pair-fed controls. Aldosterone secretion by the magnesium-depleted animals was increased, while corticosterone secretion was decreased. Altered steroid secretion adequately explains the altered sodium and potassium metabolism. (Endocrinology80: 969, 1967)

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Available abstract

Decreased muscle potassium and increased sodium in rats made magnesium deficient suggested the possibility of increased aldosterone secretion. Muscle and plasma electrolytes and secretion of aldosterone and corticosterone in magnesium-deficient rats were compared with the same values in pair-fed controls. Aldosterone secretion by the magnesium-depleted animals was increased, while corticosterone secretion was decreased. Altered steroid secretion adequately explains the altered sodium and potassium metabolism. (Endocrinology80: 969, 1967)

Key concepts: Aldosterone, Endocrinology, Internal medicine, Secretion, Corticosterone, Magnesium, Sodium, Potassium

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