2003•Annals of the New York Academy of SciencesRequires access

Characterization of Early Developments in the Splenic Leukocyte Transcriptome of NOD Mice

Ivan Gerling, Cherie F. Ali, Nataliya I. Lenchik

Abstract

Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice.

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Key concepts: Transcriptome, Nod, Biology, Gene expression, Gene, Gene expression profiling, Immunology, Cell biology