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1995•Trends in MicrobiologyOpen access

Determinants of cell entry and intracellular survival of Mycobacterium tuberculosis

Lee W. Riley

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Abstract

The ability of Mycobacterium tuberculosis to sustain a chronic infection and cause disease in a subset of those infected depends on its products--virulence factors--that enable the organism to enter and survive indefinitely inside mononuclear phagocytic cells by subverting cellular antimicrobial mechanisms. Characterizing these factors is essential to understanding the pathogenesis of M. tuberculosis.

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The ability of Mycobacterium tuberculosis to sustain a chronic infection and cause disease in a subset of those infected depends on its products--virulence factors--that enable the organism to enter and survive indefinitely inside mononuclear phagocytic cells by subverting cellular antimicrobial mechanisms. Characterizing these factors is essential to understanding the pathogenesis of M. tuberculosis.

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Available abstract

The ability of Mycobacterium tuberculosis to sustain a chronic infection and cause disease in a subset of those infected depends on its products--virulence factors--that enable the organism to enter and survive indefinitely inside mononuclear phagocytic cells by subverting cellular antimicrobial mechanisms. Characterizing these factors is essential to understanding the pathogenesis of M. tuberculosis.

Key concepts: Biology, Mycobacterium tuberculosis, Virulence, Tuberculosis, Microbiology, Intracellular, Pathogenesis, Organism

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