1991•Radiation ResearchRequires access

Role of Neurotensin in Radiation-Induced Hypothermia in Rats

Sathasiva B. Kandasamy, Walter A. Hunt, Alan H. Harris

Abstract

The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin.

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Key concepts: Neurotensin, Hypothermia, Histamine, Disodium cromoglycate, Neuropeptide, Endocrinology, Internal medicine, Medicine