1984•Japanese Heart JournalOpen access

Preventive Effect on Stroke of a Calcium Antagonist and Its Mechanisms in SHR

Yasuo Nara, Motoki Tagami, Katsumi Ikeda, Masayuki Mano, Masahiro Kihara, Ryoichi Horie, Yukio Yamori

Abstract

In SHR, a Ca2+ antagonist, Diltiazem significantly reduced the incidence of stroke. Thymidine incorporation into cultured smooth muscle cells was suppressed by 10-4 M Diltiazem, so that strain difference disappeared. By autoradiogram Diltiazem was observed in cardiomyocyte organella and tended to concentrate finally on mitochondria.

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Key concepts: Diltiazem, Antagonist, Calcium, Stroke (engine), Mitochondrion, Internal medicine, Chemistry, Strain (injury)