2003•American Journal of TherapeuticsRequires access

Severe Bleeding Symptoms in Refractory Idiopathic Thrombocytopenic Purpura: A Case Successfully Treated With Melatonin

Mauro Todisco, Piergiorgio Casaccia, Nazzareno Rossi

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Abstract

The prognosis of patients with idiopathic thrombocytopenic purpura refractory to corticosteroids and splenectomy (refractory ITP) is poor; these patients present high morbidity from disease and its treatment and have a mortality rate of approximately 16%. A patient is reported with severe bleeding symptoms related to refractory ITP successfully treated with melatonin.

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What this paper is about

The prognosis of patients with idiopathic thrombocytopenic purpura refractory to corticosteroids and splenectomy (refractory ITP) is poor; these patients present high morbidity from disease and its treatment and have a mortality rate of approximately 16%. A patient is reported with severe bleeding symptoms related to refractory ITP successfully treated with melatonin.

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OpenAlex reports 14 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The prognosis of patients with idiopathic thrombocytopenic purpura refractory to corticosteroids and splenectomy (refractory ITP) is poor; these patients present high morbidity from disease and its treatment and have a mortality rate of approximately 16%. A patient is reported with severe bleeding symptoms related to refractory ITP successfully treated with melatonin.

Key concepts: Medicine, Refractory (planetary science), Thrombocytopenic purpura, Splenectomy, Melatonin, Internal medicine, Surgery, Platelet

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