Synthesis of the C1−C12 Fragment of the Tedanolides. Aldol−Non-Aldol Aldol Approach
Michael E. Jung, Dongwon Yoo
Abstract
Michael E. Jung, Dongwon Yoo
Abstract
The combination of highly stereoselective non-aldol aldol and aldol processes allows the preparation of the completely protected C1-C12 fragment 2 of the novel macrocyclic cytotoxic agent tedanolide 1.
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The combination of highly stereoselective non-aldol aldol and aldol processes allows the preparation of the completely protected C1-C12 fragment 2 of the novel macrocyclic cytotoxic agent tedanolide 1.
Key concepts: Aldol reaction, Chemistry, Fragment (logic), Stereoselectivity, Stereochemistry, Aldol condensation, Organic chemistry, Catalysis