1976New England Journal of MedicineRequires access

Pulmonary Hemorrhage in Goodpasture's Syndrome

Alfred P. Fishman

Open publisher page 5 citations

Abstract

Goodpasture's syndrome is a distinctive combination of glomerulonephritis and pulmonary hemorrhage mediated by antibodies to the basement membranes of the glomeruli, and probably also of the lungs.1 Although the syndrome is uncommon, it has excited widespread interest because of its conceptual implications for immunology and because it is usually a harbinger of impending doom.About half the patients with Goodpasture's syndrome die of asphyxia after a pulmonary hemorrhage. Accordingly, it is not surprising that physicians generally become apprehensive at the first signs of pulmonary hemorrhage and are inclined to resort to drastic measures if hemorrhage persists.Unfortunately, any or all . . .

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What this paper is about

Goodpasture's syndrome is a distinctive combination of glomerulonephritis and pulmonary hemorrhage mediated by antibodies to the basement membranes of the glomeruli, and probably also of the lungs.1 Although the syndrome is uncommon, it has excited widespread interest because of its conceptual implications for immunology and because it is usually a harbinger of impending doom.About half the patients with Goodpasture's syndrome die of asphyxia after a pulmonary hemorrhage. Accordingly, it is not surprising that physicians generally become apprehensive at the first signs of pulmonary hemorrhage and are inclined to resort to drastic measures if hemorrhage persists.Unfortunately, any or all . . .

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Available abstract

Goodpasture's syndrome is a distinctive combination of glomerulonephritis and pulmonary hemorrhage mediated by antibodies to the basement membranes of the glomeruli, and probably also of the lungs.1 Although the syndrome is uncommon, it has excited widespread interest because of its conceptual implications for immunology and because it is usually a harbinger of impending doom.About half the patients with Goodpasture's syndrome die of asphyxia after a pulmonary hemorrhage. Accordingly, it is not surprising that physicians generally become apprehensive at the first signs of pulmonary hemorrhage and are inclined to resort to drastic measures if hemorrhage persists.Unfortunately, any or all . . .

Key concepts: Goodpasture's syndrome, Pulmonary hemorrhage, Medicine, Goodpasture syndrome, Asphyxia, Acute glomerulonephritis, Rapidly progressive glomerulonephritis, Glomerulonephritis

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