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1977•Scandinavian Journal of ImmunologyRequires access

Inhibition of B‐Cell Function by Concanavalin‐A‐Induced Suppressor Cells

F. L. Shand, Juraj Iványi

Open publisher page 10 citations

Abstract

The in vitro immune response of normal spleen cells to the thymus-independent antigen dinitrophenylated levan (DNP-LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti-sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con-A-induced suppressor cell activity.

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What this paper is about

The in vitro immune response of normal spleen cells to the thymus-independent antigen dinitrophenylated levan (DNP-LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti-sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con-A-induced suppressor cell activity.

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Available abstract

The in vitro immune response of normal spleen cells to the thymus-independent antigen dinitrophenylated levan (DNP-LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti-sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con-A-induced suppressor cell activity.

Key concepts: Concanavalin A, Suppressor, Immune system, In vitro, Spleen, Antigen, Cell, Biology

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