Strong Inverse Association of Serum Parathormone with Plasma HCO 3 in Female Hemodialysis Patients

Secondary hyperparathyroidism(SHPTH) is a common complication of chronic kidney disease and is characterized by elevated levels of serum parathyroid hormone (PTH) and abnormalities in bone and mineral metabolism. This serious disorder could be aggravated by metabolic acidosis which is a common consequence of advanced chronic renal failure and in maintenance dialysis patients. To investigate factors influencing the intensity of secondary hyperparathyroidism (SHPTH) in patients on chronic maintenance haemodialysis we tested the association of relative acidosis of hemodialysis patients with parathyroid gland activity. This is a cross-sectional study that was conducted on patients undergoing maintenance hemodialysis treatment with acetate basis dialysate and polysulfone membrane. Serum calcium (Ca), phosphorus (P), magnesium (Mg), alkaline phosphatase (ALP) and intact serum PTH (iPTH) and plasma HCO 3 were measured. A significant positive correlation of plasma HCO 3 with duration and dosage of hemodialysis were found. In all patients a significant inverse correlation of logarithm of serum iPTH with plasma HCO 3 was seen while this association was very significant in female hemodialysis patients. A strong inverse association between plasma HCO 3 and serum PTH in female gender may show the more aggressive form of SHPTH in this group.