Effect of fructose on rat lipids

Abstract Young and mature albino rats were fed Purina chow with and without fructose in the drinking water, and the lipid contents in the serum and livers were determined. Fructose elevated the serum triglyceride and caused an accumulation after 24 hr of liver triglyceride in fed but not fasted mature rats. In young male rats, the liver triglyceride was increased initially but was not found after 10 days. Serum phospholipids were increased in young and mature rats; the content and specific activity of the high density (HD)‐lipoproteins being increased in young rats. In vivo incorporation of labeled acetate into liver cholesterol was reduced. Results suggest that fructose or triglyceride metabolism, or both, in rats differ with age.