2014•Chemical CommunicationsRequires access

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

Jung Min Shin, Seol-Hee Kim, Thavasyappan Thambi, Dong Gil You, Jueun Jeon, Jong Oh Lee, Bong Youl Chung, Dong‐Gyu Jo, Jae Hyung Park

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Abstract

In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

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Key concepts: Rheumatoid arthritis, Methotrexate, Hyaluronic acid, Conjugate, Medicine, Pharmacology, Internal medicine, Mathematics