2013•Biochemical PharmacologyRequires access

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A

Gareth A. Prosser, Janine N. Copp, Alexandra M. Mowday, Christopher P. Guise, Sophie P. Syddall, Elsie M. Williams, Claire N. Horvat, Pearl M. Swe, Amir Ashoorzadeh, William Alexander Denny, Jeff Bruce Smaill, Adam Vorn Patterson, David F. Ackerley

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Key concepts: Nitroreductase, Prodrug, Enzyme, Transfection, Biochemistry, Escherichia coli, Oxidoreductase, Chemistry