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Intrinsic-factor Antibody and Absorption of Vitamin B 12 in Pernicious Anaemia

Michael S. Rose, I. Chanarin

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Abstract

The mean urinary excretion in a vitamin-B(12) absorption (Schilling) test in control subjects was 19.2% and in pernicious anaemia when given with additional intrinsic factor was as follows: no intrinsic-factor antibodies demonstrable 19.3%, antibodies in serum only 14.4%, antibodies in gastric juice only 11.1%, and antibodies in both serum and gastric juice 8.4%. It is concluded that intrinsic-factor antibody exerts an adverse effect on vitamin-B(12) absorption in most patients with pernicious anaemia.

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The mean urinary excretion in a vitamin-B(12) absorption (Schilling) test in control subjects was 19.2% and in pernicious anaemia when given with additional intrinsic factor was as follows: no intrinsic-factor antibodies demonstrable 19.3%, antibodies in serum only 14.4%, antibodies in gastric juice only 11.1%, and antibodies in both serum and gastric juice 8.4%. It is concluded that intrinsic-factor antibody exerts an adverse effect on vitamin-B(12) absorption in most patients with pernicious anaemia.

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Available abstract

The mean urinary excretion in a vitamin-B(12) absorption (Schilling) test in control subjects was 19.2% and in pernicious anaemia when given with additional intrinsic factor was as follows: no intrinsic-factor antibodies demonstrable 19.3%, antibodies in serum only 14.4%, antibodies in gastric juice only 11.1%, and antibodies in both serum and gastric juice 8.4%. It is concluded that intrinsic-factor antibody exerts an adverse effect on vitamin-B(12) absorption in most patients with pernicious anaemia.

Key concepts: Intrinsic factor, Pernicious anaemia, Vitamin B12, Antibody, Cyanocobalamin, Internal medicine, Absorption (acoustics), Excretion

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