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1979•European Journal of EndocrinologyRequires access

PROLIFERATION OF PERIPHERAL LYMPHOID CELLS FROM EUTHYROID AND HYPERTHYROID INDIVIDUALS CULTURED WITH HUMAN THYROGLOBULIN

Henric Blomgren, G. E. F. Lundell

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Abstract

Peripheral lymphoid cells from euthyroid and hyperthyroid subjects were tested for proliferative responses to human thyroglobulin in vitro using [3H] thymidine incorporation as assay. Non-fractionated lymphoid cells from both groups displayed weak stimulation. Using a rosette technique for separating sub-populations of lymphoid cells it was concluded that T-cells constituted the responding cells. The results indicate that both hyperthyroid and euthyroid subjects possess clones of T-cells which are reactive against human thyroglobulin.

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Peripheral lymphoid cells from euthyroid and hyperthyroid subjects were tested for proliferative responses to human thyroglobulin in vitro using [3H] thymidine incorporation as assay. Non-fractionated lymphoid cells from both groups displayed weak stimulation. Using a rosette technique for separating sub-populations of lymphoid cells it was concluded that T-cells constituted the responding cells. The results indicate that both hyperthyroid and euthyroid subjects possess clones of T-cells which are reactive against human thyroglobulin.

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Available abstract

Peripheral lymphoid cells from euthyroid and hyperthyroid subjects were tested for proliferative responses to human thyroglobulin in vitro using [3H] thymidine incorporation as assay. Non-fractionated lymphoid cells from both groups displayed weak stimulation. Using a rosette technique for separating sub-populations of lymphoid cells it was concluded that T-cells constituted the responding cells. The results indicate that both hyperthyroid and euthyroid subjects possess clones of T-cells which are reactive against human thyroglobulin.

Key concepts: Euthyroid, Thyroglobulin, Internal medicine, Endocrinology, In vitro, Thyroid, Stimulation, Lymphatic system

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PROLIFERATION OF PERIPHERAL LYMPHOID CELLS FROM EUTHYROID AND HYPERTHYROID INDIVIDUALS CULTURED WITH HUMAN THYROGLOBULIN — Research Paper | ScholarLens