2009•Journal of Pharmacy and PharmacologyRequires access
Animal studies supporting the inhibition of mast cell activation byEriobotrya japonicaseed extract
Masahide Onogawa, Guangchen Sun, Daisuke Takuma, Atsuhide Hamada, Junko Yokota, Saburo Yoshioka, Masahiko Kusunose, Mitsuhiko Miyamura, Shojiro Kyotani, Yutaka Nishioka
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Abstract
OBJECTIVES: The potent antioxidant activity of Eriobotrya japonica seed extract (ESE) and its usefulness in the prevention and treatment of various disorders has been reported previously. Its antioxidant activity associated with beta-sitosterol and polyphenols contained in the extract was also validated. In this study, anti-allergic activity of Eriobotrya japonica seed extract was investigated. METHODS: The inhibition of histamine release-mediated type 1 allergy by Eriobotrya japonica seed extract was used as an index. KEY FINDINGS: The administration of this extract inhibited histamine release from rat mast cells, suggesting its usefulness in allergic disease treatment. In an experiment using a guinea-pig allergic rhinitis model, this extract reduced the frequency of sneezing and nose-scratching. CONCLUSIONS: These results suggest that Eriobotrya japonica seed extract may contribute to the relief of allergic disease-related symptoms.