Comparison Between Pilocarpine and Timolol on Diurnal Pressures in Open-Angle Glaucoma

In 14 eyes with open-angle glaucoma, 2% pilocarpine hydrochloride given four times a day was compared with timolol given twice daily in its effect on intraocular pressure around the clock. The findings suggest that the timolol produced a greater reduction in pressure than pilocarpine and that, in 50% of the diurnal curves, the timolol curve showed smaller swings in IOP.