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Repair of the Ultraviolet-Irradiated Male Genome in Fertilized Mouse Eggs

Brigitte F. Brandriff, Roger A. Pedersen

Open publisher page 107 citations

Abstract

Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.

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What this paper is about

Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.

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OpenAlex reports 107 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.

Key concepts: Pronucleus, Zygote, Gamete, Biology, Human fertilization, Sperm, Ultraviolet light, DNA repair

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