Repair of the Ultraviolet-Irradiated Male Genome in Fertilized Mouse Eggs
Brigitte F. Brandriff, Roger A. Pedersen
Abstract
Brigitte F. Brandriff, Roger A. Pedersen
Abstract
Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.
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Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.
Key concepts: Pronucleus, Zygote, Gamete, Biology, Human fertilization, Sperm, Ultraviolet light, DNA repair