Studies on Experimental Proteinuria I

Experimental proteinuria was induced in-10 rats receiving equal amounts of a renal antiserum prepared according to Smadel and Farr. The course of the disease was followed for 43 days, after which time the animals were killed. The following results were obtained:1. Seven of the animals developed a severe proteinuria which reached its maximum during the first 3 days after the injection and then slowly decreased but did not reach the normal level by the end of the experiment. One animal reached the normal level of proteinuria in a week, the other two animals did not develop any marked proteinuria at all. The proteinuria showed parallelism to water output in forced oliguria and polyuria. Oliguria occurred 6 times in all in three of the animals. At the end of the experiment all of the animals showed an intact diuresis regulating power.2. The electrophoresis at the end of the observation time indicated rather small changes in serum proteins: a small decrease of albumin in most cases and a distinct increase of a...