1971•Journal of Pharmacy and PharmacologyRequires access

Uptake and metabolism of β-phenethylamine and tyramine in mouse brain and heart slices

Svante B. Ross, Anna L. Rényi

Abstract

Abstract Tritium labelled β-phenethylamine and tyramine were incubated with slices of mouse brain and heart. Cocaine (3 × 10−5M) caused a reduction of 30% in the uptake of tyramine as well as in the formation of its metabolite 4-hydroxyphenylacetic acid. Cocaine had no effect on either the uptake of phenethylamine nor its deamination to phenylacetic acid.

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Key concepts: Phenethylamine, Tyramine, Phenylacetic acid, Metabolite, Deamination, Chemistry, Metabolism, Pharmacology