1948•Japanese medical journalOpen access

THE INFLUENCE OF THE PHENYLACETIC ACID, PARANITROPHENYL ACETIC ACID, PARAAMINOPHENYLACETIC ACID AND PARAOXYPHENYLACETIC ACID ON THE PENICILLIN PRODUCTION BY SURFACE CULTURE

HAMAO UMEZAWA, Satiro Suzuki, Tatsuro Shigei, TOMIO TAKEUCHI

Abstract

Phenylacetic acid is usually added to culture media, in order to increase the penicillin production. This effect is explained by assuming that the phenylacetic acid is utilized as one component of penicillin (1.2) . Then it can be expected that its derivatives may also increase the penicillin production and make the special penicillin. But from our experiment it seems that almost all the penicillin produced in the culture media added with paranitro-, paraamino-, or paraoxy-phenyl-acetic acid is the ordinary natural penicillin, even though they can increase the penicillin production.

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Key concepts: Phenylacetic acid, Penicillin, Acetic acid, Chemistry, Microbiology, Antibiotics, Biochemistry, Biology