2006•FEBS LettersOpen access

Ribosomal protein S1 induces a conformational change of the 30S ribosomal subunit

S. Ch. Agalarov, Artem Kalinichenko, Aigar Kommer, Alexander S. Spirin

Abstract

A comparative study of the 30S ribosomal subunit in the complex with protein S1 and the subunit depleted of this protein has been carried out by the hot tritium bombardment method. Differences in exposure of some ribosomal proteins within the 30S subunit depleted of S1 and within the 30S-S1 complex were found. It was concluded that protein S1 binds in the region of the neck of the 30S ribosomal subunit inducing a conformational change of its structure.

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Key concepts: 30S, Ribosomal protein, Ribosomal RNA, Eukaryotic Large Ribosomal Subunit, Protein subunit, Eukaryotic Small Ribosomal Subunit, Conformational change, Chemistry