2004•Scandinavian Journal of Urology and NephrologyRequires access

Topical application of the tricyclic antidepressant doxepin can reduce dysuria and frequency

Gary McCleane

Abstract

The aim of this article is to highlight a novel treatment for the symptoms of chronic urethral and trigonal irritation. A patient with severe urethral hyperaesthesia who derived almost complete alleviation of symptoms with topical application of a tricyclic antidepressant cream is described. The possible modes of action of tricyclics when used via the topical route of administration are described. Topical application of a tricyclic antidepressant cream may alleviate the symptoms of urethral hyperaesthesia.

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Key concepts: Doxepin, Medicine, Tricyclic, Tricyclic antidepressant, Dysuria, Antidepressant, Irritation, Anesthesia