2007•Nucleosides Nucleotides & Nucleic AcidsRequires access

Hairpin Mimics with Phenanthroline- and Bipyridine-Derived Linkers

Gapian Bianké, Robert Häner

Abstract

The synthesis and structural stabilities of modified oligonucleotide hairpins containing phenanthroline- and bipyridine-modified loops is reported. Phenanthroline (phen) and bipyridine (bipy) building blocks were synthesized, incorporated into DNA-oligonucleotides, and analyzed by thermal denaturation experiments. The so modified oligomers were found to form stable hairpin structures. Tm values were not affected by divalent transition metals.

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Key concepts: Phenanthroline, Oligonucleotide, Bipyridine, Divalent, 2,2'-Bipyridine, Chemistry, DNA, Combinatorial chemistry