1982•Journal of Dental ResearchRequires access

Formation of 12L-Hydroxyeicosatetraenoic Acid (12-HETE) by Gingival Tissue

BJÖRN SIDHAGEN, Mats Hámberg, Bertil B. Fredholm

Abstract

Extracts of inflamed human gingival tissue converted exogenous [ 14 C] -arachidonic acid mainly to a non-prostaglandin metabolite. This metabolite was identified as 12-hydroxyeicosatetraenoic acid (12-HETE) by gas-liquid chromatography-mass-spectometry. Endogenous arachidonic acid was also converted to 12-HETE. Significant formation of PGF 2α , PGD2, PGI 2 , Thromboxane B, or 12-HHT could not be detected, but, in occasional experiments, significant conversion of arachidonic acid to PGE 2 was found.

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Key concepts: Arachidonic acid, Hydroxyeicosatetraenoic acid, Metabolite, Endogeny, Chemistry, Prostaglandin, Thromboxane, Prostaglandin f