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2009•International Archives of Allergy and Applied ImmunologyRequires access

Stimulation of Histamine-Forming Capacity by Antigen in Sensitized Human Leucocytes

E. S. K. Assem, H.O. Schild, M. R. Vickers

Open publisher page 18 citations

Abstract

(1) Three types of experiments showed that histamine is formed during the reaction of antigen (D. pteronyssinus) with leucocytes of allergic human subjects: (a) total histamine of leucocytes (extracted + released) was increased; (b) histamine-forming capacity (HFC) of leucocytes was stimulated by antigen in vitro; (c) HFC of leucocytes was stimulated by injecting antigen in vivo. (2) Stimulation of HFC of leucocytes by antigen may provide a new and sensitive (though cumbersome) in vitro test of allergy.

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What this paper is about

(1) Three types of experiments showed that histamine is formed during the reaction of antigen (D. pteronyssinus) with leucocytes of allergic human subjects: (a) total histamine of leucocytes (extracted + released) was increased; (b) histamine-forming capacity (HFC) of leucocytes was stimulated by antigen in vitro; (c) HFC of leucocytes was stimulated by injecting antigen in vivo. (2) Stimulation of HFC of leucocytes by antigen may provide a new and sensitive (though cumbersome) in vitro test of allergy.

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OpenAlex reports 18 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

(1) Three types of experiments showed that histamine is formed during the reaction of antigen (D. pteronyssinus) with leucocytes of allergic human subjects: (a) total histamine of leucocytes (extracted + released) was increased; (b) histamine-forming capacity (HFC) of leucocytes was stimulated by antigen in vitro; (c) HFC of leucocytes was stimulated by injecting antigen in vivo. (2) Stimulation of HFC of leucocytes by antigen may provide a new and sensitive (though cumbersome) in vitro test of allergy.

Key concepts: Histamine, Stimulation, Antigen, In vitro, Immunology, In vivo, Allergy, Chemistry

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