SH2 domain specificity and activity modified by a single residue
Luc E. M. Marengère, Zhou Songyang, Gerald D. Gish, Michael D. Schaller, J. Thomas Parsons, Michael Stern, Lewis C. Cantley, Tony J. Pawson
Abstract
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Luc E. M. Marengère, Zhou Songyang, Gerald D. Gish, Michael D. Schaller, J. Thomas Parsons, Michael Stern, Lewis C. Cantley, Tony J. Pawson
Abstract
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Key concepts: SH2 domain, GRB2, Proto-oncogene tyrosine-protein kinase Src, Phosphotyrosine-binding domain, Tyrosine, Signal transducing adaptor protein, Residue (chemistry), Biochemistry