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1958•New England Journal of MedicineRequires access

Early Jaundice in the Newborn

Fred H. Allen

Open publisher page 5 citations

Abstract

SEVERE jaundice in the neonatal period has come to be recognized as one of the major problems of that crucial time of life. Whether caused by erythroblastosis fetalis (due to ABO, Rh and its subtypes, or some other blood-group factor) or an infectious disease, or even if it is simply severe "physiologic" icterus, marked jaundice may be accompanied by damage to the brain. This brain damage (kernicterus) is believed to be caused by high concentrations of indirect bilirubin. It is considered preventable by exchange transfusions given in time, and serum bilirubin levels are considered a reliable guide to the necessity . . .

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What this paper is about

SEVERE jaundice in the neonatal period has come to be recognized as one of the major problems of that crucial time of life. Whether caused by erythroblastosis fetalis (due to ABO, Rh and its subtypes, or some other blood-group factor) or an infectious disease, or even if it is simply severe "physiologic" icterus, marked jaundice may be accompanied by damage to the brain. This brain damage (kernicterus) is believed to be caused by high concentrations of indirect bilirubin. It is considered preventable by exchange transfusions given in time, and serum bilirubin levels are considered a reliable guide to the necessity . . .

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

SEVERE jaundice in the neonatal period has come to be recognized as one of the major problems of that crucial time of life. Whether caused by erythroblastosis fetalis (due to ABO, Rh and its subtypes, or some other blood-group factor) or an infectious disease, or even if it is simply severe "physiologic" icterus, marked jaundice may be accompanied by damage to the brain. This brain damage (kernicterus) is believed to be caused by high concentrations of indirect bilirubin. It is considered preventable by exchange transfusions given in time, and serum bilirubin levels are considered a reliable guide to the necessity . . .

Key concepts: Kernicterus, ABO incompatibility, Jaundice, Medicine, Erythroblastosis fetalis, Exchange transfusion, ABO blood group system, Hemolytic disease of the newborn (ABO)

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