Pharmacology of octopamine‐, dopamine‐, and 5‐hydroxytryptamine‐stimulated cyclic amp accumulation in the corpus cardiacum of the american cockroach, Periplaneta americana L

Abstract A variety of potential receptor agonists were incubated with isolated corpora cardiaca from the American cockroach Periplaneta americana to determine their effects on cyclic AMP production in this gland. Octopamine, dopamine, and 5‐hydroxytryptamine elevated cyclic AMP levels in a dose‐dependent manner with estimated Ka values of 15.8, 1.7, and 1.1 m̈M, respectively, and their stimulation was found to be additive. Several vertebrate receptor antagonists were tested against the three amines and a preliminary pharmacological profile developed.