2009•Canadian Journal of ChemistryRequires access

Synthesis of arylbromides from arenes and N -bromosuccinimide (NBS) in acetonitrile — A convenient method for aromatic bromination

Eli Zysman‐Colman, Karla I. Arias, Jay S. Siegel

Abstract

Regioselective and chemoselective electrophilic bromination of a wide series of activated arenes using N-bromosuccinimide (NBS) in acetonitrile occurs readily. Environmentally friendly conditions, large substrate scope, and ease of synthesis enhance the utility of this method over other electrophilic bromination conditions.

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Key concepts: Halogenation, N-Bromosuccinimide, Chemistry, Acetonitrile, Regioselectivity, Electrophile, Organic chemistry, Substrate (aquarium)