1995•Cleveland Clinic Journal of MedicineRequires access

Methotrexate in rheumatoid arthritis: when NSAIDs fail

Donald G. Vidt, John A. Flynn, David B. Hellmann

Abstract

Methotrexate has become the agent of choice for rheumatoid arthritis that does not respond to nonsteroidal anti-inflammatory drugs. In appropriately selected patients and with diligent monitoring, methotrexate in low weekly doses is effective and has a much better safety profile than was originally perceived.

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Key concepts: Medicine, Rheumatoid arthritis, Methotrexate, Nonsteroidal, Internal medicine, Arthritis, Pharmacology