2002•Angewandte Chemie International EditionRequires access

A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins

Malin Andersson, Robert Epple, Valery V. Fokin, K. Barry Sharpless

Abstract

Simple hydroxyamino acid derivatives act as chiral ligands in osmium-catalyzed dihydroxylation and aminohydroxylation of olefins (see scheme). These are the first examples of asymmetric osmium-catalyzed processes proceeding in the second catalytic cycle with resident ligands on the metal center.

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Key concepts: Dihydroxylation, Osmium, Catalysis, Catalytic cycle, Chemistry, Hydroxylation, Enantioselective synthesis, Combinatorial chemistry