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2008•NeuroendocrinologyRequires access

Vasopressin and Oxytocin Content of Microdissected Hypothalamic Areas in Rats with Hereditary Diabetes insipidus

Julia M. George, J. A. H. Forrest

Open publisher page 11 citations

Abstract

Vasopressin was virtually absent from 5 microdissected hypothalamic areas and from the posterior pituitary glands of homozygous Brattleboro rats. The oxytocin concentration was normal in all these areas except for the arcuate nucleus, where it was absent. These results support the concept that Brattleboro rats have a specific defect in biosynthesis of vasopressin. The significance of the absence of oxytocin from the arcuate nucleus in these rats remains to be determined.

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What this paper is about

Vasopressin was virtually absent from 5 microdissected hypothalamic areas and from the posterior pituitary glands of homozygous Brattleboro rats. The oxytocin concentration was normal in all these areas except for the arcuate nucleus, where it was absent. These results support the concept that Brattleboro rats have a specific defect in biosynthesis of vasopressin. The significance of the absence of oxytocin from the arcuate nucleus in these rats remains to be determined.

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Available abstract

Vasopressin was virtually absent from 5 microdissected hypothalamic areas and from the posterior pituitary glands of homozygous Brattleboro rats. The oxytocin concentration was normal in all these areas except for the arcuate nucleus, where it was absent. These results support the concept that Brattleboro rats have a specific defect in biosynthesis of vasopressin. The significance of the absence of oxytocin from the arcuate nucleus in these rats remains to be determined.

Key concepts: Oxytocin, Vasopressin, Diabetes insipidus, Endocrinology, Internal medicine, Posterior pituitary, Hypothalamus, Arcuate nucleus

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Vasopressin and Oxytocin Content of Microdissected Hypothalamic Areas in Rats with Hereditary Diabetes insipidus — Research Paper | ScholarLens