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1994•Annals of Clinical PsychiatryRequires access

Bupropion/Nortriptyline Combination for Refractory Depression

Jeffrey Apter, Stuart Kushner, Robert L. Woolfolk

Open publisher page 15 citations

Abstract

Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.

About this research paper

What this paper is about

Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.

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OpenAlex reports 15 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.

Key concepts: Nortriptyline, Bupropion, Polypharmacy, Antidepressant, Tricyclic, Refractory (planetary science), Tricyclic antidepressant, Depression (economics)

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