2000•Journal of Natural ProductsRequires access

A New 2D-TLC Bioautography Method for the Discovery of Novel Antifungal Agents To Control Plant Pathogens

David E. Wedge, Dale G. Nagle

Abstract

A new bioassay has been developed combining the simplicity of direct bioautography with the improved chromatographic resolution of 2D-TLC. Mixtures of structurally diverse antifungal agents were tested to establish the validity and utility of this method in the discovery of new natural products with activity against agriculturally important fungal pathogens.

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Key concepts: Antifungal, Bioassay, Chromatography, Resolution (logic), Natural compound, Traditional medicine, Biology, Chemistry