1958•Canadian Journal of Biochemistry and PhysiologyRequires access
OBSERVATIONS ON THE UPTAKE OF RADIOSULPHATE BY THE GASTRIC TISSUE AND GASTRIC SECRETION IN HISTAMINE-TREATED GUINEA PIGS
K. Kowalewski, H. T. G. Williams
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Abstract
The effect of histamine on the uptake of radiosulphate by gastric tissue and gastric juice in guinea pigs was investigated. Radioactivity was recorded 4 hours after the administration of S35-labelled sulphate to normal controls and to histamine-treated animals.The radioactivity of fractions considered to contain sulphated mucopolysaccharides was also investigated.The uptake of radiosulphate by gastric tissue and juice was significantly higher in histamine-treated animals than in control guinea pigs.The S35 uptake by gastric sulphomucopolysaccharides was considered to represent the concentration of isotope by mucous cells and its secretion. This selective uptake was also markedly effected by histamine.Histamine may be a stimulant of the gastric mucous cells under the experimental conditions described.