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DNA REPAIR IN THE VARIABLE PLATYFISH (Xiphophorus variatus) IRRADIATED in vivo WITH ULTRAVIOLET B LIGHT

David L. Mitchell, J. Travis Scoggins, Donald C. Morizot

Open publisher page 49 citations

Abstract

Dark- and light-dependent DNA repair processes were studied in vivo in the variable platyfish, Xiphophorus variatus. Excision (dark) repair of the (6-4) photoproduct was more efficient than that of the cyclobutane dimer with approximately 70% of the (6-4) photoproducts removed by 24 h post-UVB radiation compared to approximately 30% of the cyclobutane dimers. Exposure to photoreactivating light resulted in rapid loss of most (> 90%) of the cyclobutane dimers and increased excision repair of the (6-4) photoproduct. Preexposure to photoreactivating light 8 h prior to UVB radiation increased the rate of photoreactivation two-fold.

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What this paper is about

Dark- and light-dependent DNA repair processes were studied in vivo in the variable platyfish, Xiphophorus variatus. Excision (dark) repair of the (6-4) photoproduct was more efficient than that of the cyclobutane dimer with approximately 70% of the (6-4) photoproducts removed by 24 h post-UVB radiation compared to approximately 30% of the cyclobutane dimers. Exposure to photoreactivating light resulted in rapid loss of most (> 90%) of the cyclobutane dimers and increased excision repair of the (6-4) photoproduct. Preexposure to photoreactivating light 8 h prior to UVB radiation increased the rate of photoreactivation two-fold.

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Available abstract

Dark- and light-dependent DNA repair processes were studied in vivo in the variable platyfish, Xiphophorus variatus. Excision (dark) repair of the (6-4) photoproduct was more efficient than that of the cyclobutane dimer with approximately 70% of the (6-4) photoproducts removed by 24 h post-UVB radiation compared to approximately 30% of the cyclobutane dimers. Exposure to photoreactivating light resulted in rapid loss of most (> 90%) of the cyclobutane dimers and increased excision repair of the (6-4) photoproduct. Preexposure to photoreactivating light 8 h prior to UVB radiation increased the rate of photoreactivation two-fold.

Key concepts: Photolyase, Pyrimidine dimer, Cyclobutane, Xiphophorus, In vivo, DNA repair, DNA, Ultraviolet light

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DNA REPAIR IN THE VARIABLE PLATYFISH (Xiphophorus variatus) IRRADIATED in vivo WITH ULTRAVIOLET B LIGHT — Research Paper | ScholarLens