2015•Chemical CommunicationsRequires access
Acyclic l -threoninol nucleic acid ( l -aTNA) with suitable structural rigidity cross-pairs with DNA and RNA
Keiji Murayama, Hiromu Kashida, Hiroyuki Asanuma
Open publisher page 59 citations
Abstract
We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.