2011•European Journal of Clinical PharmacologyRequires access

Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

Sam S Rebello, Sally Zhao, Sam Hariry, Marion Dahlke, Natalya Alexander, Arpine Vapurcuyan, Imad H. Hanna, Venkateswar R. Jarugula

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Key concepts: Grapefruit juice, Aliskiren, Pharmacology, Pharmacokinetics, Chemistry, Organic anion-transporting polypeptide, Cmax, Fexofenadine

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Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects — Research Paper | ScholarLens