2001•Journal of VirologyOpen access

Discovery of a Novel Murine Type C Retrovirus by Data Mining

Lindell Bromham, Francis Clark, Jeff J. McKee

Abstract

Analysis of genomic and expression data allows both identification and characterization of novel retroviruses. We describe a recombinant type C murine retrovirus, similar to the Mus dunni endogenous retrovirus, with VL30-like long terminal repeats and murine leukemia virus-like coding sequences. This virus is present in multiple copies in the mouse genome and expressed in a range of mouse tissues.

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Key concepts: Retrovirus, Biology, Endogenous retrovirus, Murine leukemia virus, Long terminal repeat, Genome, Virology, Recombinant DNA