1991•SEIBUTSU BUTSURI KAGAKUOpen access

Additional lactate dehydrogenase isoenzyme in serum of a patient with malaria tertian.

Tatsuo Tozawa, Junko Kuwahara

Abstract

Anomalous LDH electrophoretic pattern in serum from a patient with malaria tertian, an additional band being present between LDH 3 and LDH 4, apparently due to the existence of malarial LDH is described.To our knowledge, this phenomenon has not been reported.The band was found to be eluted with normal LDH isoenzymes in the serum during gel filtration, and its activity was lactate dependent.However, data on enzymatical and immunochemical properties of the band indicated that it differed from human LDH.The band was also found in a hemolysate from the patient's blood cells, and the band appearance in the patient's serum and hemolysate was associated with the presence of maralia parasites in the erythrocytes.

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Key concepts: Lactate dehydrogenase, L-Lactate dehydrogenase, Malaria, Biochemistry, Andrology, Biology, Medicine, Enzyme