Macroamylasaemia - a prognostic marker in a syndrome of malabsorption and complete villous atrophy? An uncommon clinical condition

We report a rare case of chronic persistent hyperamylasaemia secondary to macroamylasaemia in association with coeliac disease in a 56-year-old woman. Her symptoms, including macroamylasaemia, ebbed away following commencement of a gluten free diet. Only four cases of a similar nature have been described in the literature. The differential diagnosis of macroamylasaemia should include coeliac disease, and an awareness of this association might obviate a variety of unnecessary diagnostic investigations.