2008•HaematologicaOpen access

Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies

C. Zhao, X. Li, Feng Zhang, Lei Wang, Jun Peng, Ming Hou

Abstract

Idiopathic thrombocytopenic purpura (ITP) is a common hematologic disorder manifested by autoantibody-mediated platelet destruction. In the majority of ITP patients, autoantibodies were found to be specific to GPIIb/IIIa or GPIb/IX.[1][1] It may not only damage platelets via the reticuloendothelial

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Key concepts: Autoantibody, Platelet, Thrombocytopenic purpura, Medicine, Immunology, Mononuclear phagocyte system, Purpura (gastropod), Cytotoxic T cell