2001•Current Medicinal ChemistryRequires access

Biological Applications of Hammerhead Ribozymes as Anti-viral Molecules

Brooke Lustig, Kuan‐Teh Jeang

Abstract

Ribozymes are catalytic RNAs that can cleave substrate RNAs in a sequence specific manner. Here we survey, in brief, the structure of hammerhead and hairpin ribozymes and discuss their applications as molecular antiviral molecules for HIV-1. Keywords: Hammerhead Ribozymes, Anti-viral Molecules, RIBOZYMES, HAMMERHEAD RIBOZYME

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Available abstract

Key concepts: Ribozyme, Ligase ribozyme, Hammerhead ribozyme, Cleave, Hairpin ribozyme, Computational biology, Mammalian CPEB3 ribozyme, RNA