2011•CirculationRequires access
Abstract 16265: Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9 With a Monoclonal Antibody REGN727/SAR236553, Effectively Reduces Low-Density-Lipoprotein Cholesterol, as Mono or Add-on Therapy in Heterozygous Familial and Non Familial Hypercholesterolemia
Gary D. Swergold, W. Smith, Scott Mellis, Douglas Logan, Cheryle Webb, Richard Wu, Yunling Du, Therese Krans, Evelyn Gasparino, Evan A. Stein
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Abstract
Since 2003 understanding of proprotein convertase subtilisin/kexin type 9 (PCSK9) has advanced from discovery to in vitro, animal, genetic and observational studies to suggest that inhibition of PC...