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1983•Journal of Heterocyclic ChemistryRequires access

On the syntheses of thiophene analogs of practolol and “reversed” practolol

J. Luis Casarrubio, Santiago Conde, Carlos J Mávita Corral, Jaime Lissavetzky

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Abstract

Abstract The synthesis of the thiophene analogs of the cardio‐selective β‐adrenergic blocking agents Practolol and “reversed” Practolol has been attempted starting from 2‐acetyl‐5‐bromothiophene. Although this synthesis worked for the second compound it was not possible to obtain the first one. From this and other results of this paper it can be deduced that the thiophene analog of Practolol must be an unstable compound.

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What this paper is about

Abstract The synthesis of the thiophene analogs of the cardio‐selective β‐adrenergic blocking agents Practolol and “reversed” Practolol has been attempted starting from 2‐acetyl‐5‐bromothiophene. Although this synthesis worked for the second compound it was not possible to obtain the first one. From this and other results of this paper it can be deduced that the thiophene analog of Practolol must be an unstable compound.

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Available abstract

Abstract The synthesis of the thiophene analogs of the cardio‐selective β‐adrenergic blocking agents Practolol and “reversed” Practolol has been attempted starting from 2‐acetyl‐5‐bromothiophene. Although this synthesis worked for the second compound it was not possible to obtain the first one. From this and other results of this paper it can be deduced that the thiophene analog of Practolol must be an unstable compound.

Key concepts: Practolol, Chemistry, Thiophene, Blocking (statistics), Combinatorial chemistry, Stereochemistry, Organic chemistry, Internal medicine

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