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2003•FEBS LettersRequires access

Inhibition of influenza A virus sialidase activity by sulfatide

Takashi Suzuki, Tadanobu Takahashi, Daisuke Nishinaka, Masanori Murakami, Satoshi Fujii, Kazuya I.P.J. Hidari, Daisei Miyamoto, Yu‐Teh Li, Yasuo Suzuki

Open publisher page 23 citations

Abstract

Sulfatide, which binds to influenza A viruses and prevents the viral infection, was found to inhibit the sialidase activities of influenza A viruses in a pH-dependent manner. The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions.

About this research paper

What this paper is about

Sulfatide, which binds to influenza A viruses and prevents the viral infection, was found to inhibit the sialidase activities of influenza A viruses in a pH-dependent manner. The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions.

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OpenAlex reports 23 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Sulfatide, which binds to influenza A viruses and prevents the viral infection, was found to inhibit the sialidase activities of influenza A viruses in a pH-dependent manner. The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions.

Key concepts: Sialidase, Virus, Human influenza, Virology, Influenza A virus, Neuraminidase, Chemistry, Microbiology

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