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1977•Acta PaediatricaRequires access

THE EFFECTIVENESS OF PHENOBARBITAL IN THE PREVENTION OF RECURRENT FEBRILE CONVULSIONS IN CHILDREN WITH AND WITHOUT A HISTORY OF PRE‐, PERI‐ AND POSTNATAL ABNORMALITIES

Sheldon M. Wolf

Open publisher page 21 citations

Abstract

Three hundred children who had an initial febrile convulsion were divided into two groups. In one group were children with a single brief generalized initial febrile seizure and no history of pre-, peri- or postnatal abnormalities which might suggest the possibility of brain damage and in the other group those with such abnormalities and/or a "severe" initial febrile convulsion. Daily phenobarbital produced a significant decrease in febrile seizure recurrences in both groups, as compared to children who received phenobarbital at the onset of fever and no phenobarbital prophylaxis. "Intermitten" phenobarbital given at the onset of fever did not produce a significant difference in recurrence rate as compared with no phenobarbital.

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What this paper is about

Three hundred children who had an initial febrile convulsion were divided into two groups. In one group were children with a single brief generalized initial febrile seizure and no history of pre-, peri- or postnatal abnormalities which might suggest the possibility of brain damage and in the other group those with such abnormalities and/or a "severe" initial febrile convulsion. Daily phenobarbital produced a significant decrease in febrile seizure recurrences in both groups, as compared to children who received phenobarbital at the onset of fever and no phenobarbital prophylaxis. "Intermitten" phenobarbital given at the onset of fever did not produce a significant difference in recurrence rate as compared with no phenobarbital.

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OpenAlex reports 21 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Three hundred children who had an initial febrile convulsion were divided into two groups. In one group were children with a single brief generalized initial febrile seizure and no history of pre-, peri- or postnatal abnormalities which might suggest the possibility of brain damage and in the other group those with such abnormalities and/or a "severe" initial febrile convulsion. Daily phenobarbital produced a significant decrease in febrile seizure recurrences in both groups, as compared to children who received phenobarbital at the onset of fever and no phenobarbital prophylaxis. "Intermitten" phenobarbital given at the onset of fever did not produce a significant difference in recurrence rate as compared with no phenobarbital.

Key concepts: Medicine, Febrile convulsions, Phenobarbital, Peri, Pediatrics, Intensive care medicine, Anesthesia, Epilepsy

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THE EFFECTIVENESS OF PHENOBARBITAL IN THE PREVENTION OF RECURRENT FEBRILE CONVULSIONS IN CHILDREN WITH AND WITHOUT A HISTORY OF PRE‐, PERI‐ AND POSTNATAL ABNORMALITIES — Research Paper | ScholarLens